Phagocyte roulette in Salmonella killing

Phagocyte roulette in Salmonella killing


. 2014 Jan 15;15(1):7-8.

doi: 10.1016/j.chom.2014.01.001.


Free PMC article

Item in Clipboard


Luke A Fenlon et al.

Cell Host Microbe.


Free PMC article


Salmonella propagates in macrophages to cause life-threatening infections, but the role of neutrophils in combating Salmonella has been controversial. In this issue, Burton et al. (2014) use single cell analyses and modeling to explain the ability of Salmonella to survive in macrophages while being killed by neutrophils.

Comment on

Similar articles

  • Disparate impact of oxidative host defenses determines the fate of Salmonella during systemic infection in mice.

    Burton NA, Schürmann N, Casse O, Steeb AK, Claudi B, Zankl J, Schmidt A, Bumann D.
    Burton NA, et al.
    Cell Host Microbe. 2014 Jan 15;15(1):72-83. doi: 10.1016/j.chom.2013.12.006.
    Cell Host Microbe. 2014.

    PMID: 24439899

  • Early cellular responses to Salmonella infection: dendritic cells, monocytes, and more.

    Tam MA, Rydström A, Sundquist M, Wick MJ.
    Tam MA, et al.
    Immunol Rev. 2008 Oct;225:140-62. doi: 10.1111/j.1600-065X.2008.00679.x.
    Immunol Rev. 2008.

    PMID: 18837781


  • Cell tropism of Salmonella enterica.

    Santos RL, Bäumler AJ.
    Santos RL, et al.
    Int J Med Microbiol. 2004 Oct;294(4):225-33. doi: 10.1016/j.ijmm.2004.06.029.
    Int J Med Microbiol. 2004.

    PMID: 15532980


  • Caveolin-1-deficient mice show defects in innate immunity and inflammatory immune response during Salmonella enterica serovar Typhimurium infection.

    Medina FA, de Almeida CJ, Dew E, Li J, Bonuccelli G, Williams TM, Cohen AW, Pestell RG, Frank PG, Tanowitz HB, Lisanti MP.
    Medina FA, et al.
    Infect Immun. 2006 Dec;74(12):6665-74. doi: 10.1128/IAI.00949-06. Epub 2006 Sep 18.
    Infect Immun. 2006.

    PMID: 16982844
    Free PMC article.

  • The synergistic contribution of macrophages and antibody to protection against Salmonella typhimurium during the early phase of infection.

    Akeda H, Mitsuyama M, Tatsukawa K, Nomoto K, Takeya K.
    Akeda H, et al.
    J Gen Microbiol. 1981 Apr;123(2):209-14. doi: 10.1099/00221287-123-2-209.
    J Gen Microbiol. 1981.

    PMID: 7033456

Cited by

  • Escaping the Phagocytic Oxidative Burst: The Role of SODB in the Survival of Pseudomonas aeruginosa Within Macrophages.

    Cavinato L, Genise E, Luly FR, Di Domenico EG, Del Porto P, Ascenzioni F.
    Cavinato L, et al.
    Front Microbiol. 2020 Mar 10;11:326. doi: 10.3389/fmicb.2020.00326. eCollection 2020.
    Front Microbiol. 2020.

    PMID: 32210934
    Free PMC article.

  • Crosstalk between leukocytes triggers differential immune responses against Salmonella enterica serovars Typhi and Paratyphi.

    Salerno-Goncalves R, Kayastha D, Fasano A, Levine MM, Sztein MB.
    Salerno-Goncalves R, et al.
    PLoS Negl Trop Dis. 2019 Aug 14;13(8):e0007650. doi: 10.1371/journal.pntd.0007650. eCollection 2019 Aug.
    PLoS Negl Trop Dis. 2019.

    PMID: 31412039
    Free PMC article.

  • Malaria, anemia, and invasive bacterial disease: A neutrophil problem?

    Mooney JP, Galloway LJ, Riley EM.
    Mooney JP, et al.
    J Leukoc Biol. 2019 Apr;105(4):645-655. doi: 10.1002/JLB.3RI1018-400R. Epub 2018 Dec 20.
    J Leukoc Biol. 2019.

    PMID: 30570786
    Free PMC article.


  • The ArcAB two-component regulatory system promotes resistance to reactive oxygen species and systemic infection by Salmonella Typhimurium.

    Pardo-Esté C, Hidalgo AA, Aguirre C, Briones AC, Cabezas CE, Castro-Severyn J, Fuentes JA, Opazo CM, Riedel CA, Otero C, Pacheco R, Valvano MA, Saavedra CP.
    Pardo-Esté C, et al.
    PLoS One. 2018 Sep 4;13(9):e0203497. doi: 10.1371/journal.pone.0203497. eCollection 2018.
    PLoS One. 2018.

    PMID: 30180204
    Free PMC article.

  • Chemical Warfare at the Microorganismal Level: A Closer Look at the Superoxide Dismutase Enzymes of Pathogens.

    Schatzman SS, Culotta VC.
    Schatzman SS, et al.
    ACS Infect Dis. 2018 Jun 8;4(6):893-903. doi: 10.1021/acsinfecdis.8b00026. Epub 2018 Mar 14.
    ACS Infect Dis. 2018.

    PMID: 29517910
    Free PMC article.


Publication types

MeSH terms

Grant support

LinkOut – more resources

  • Full Text Sources

  • Medical

Latest posts